Contraindications:
1. Patients on MAOIs (approved 2 weeks after discontinuation).
2. Patients with carcinoid tumors.
3. Should not be used concurrently with medications such as: SSRIs, tricyclic antidepressants, MAOIs.
4. Should not be used concurrently with serotonin 5-HT1 receptor agonists including Naratriptan, Sumatriptan, and Zolmitriptan.
5. Patients with ischemic heart disease (Hx of myocardial infarction, angina pectoris, documented silent ischemia).
6. Patients with Hx of coronary artery spasm.
7. Uncontrolled hypertension.
8. Pregnant women and nursing mothers.
Side effects:
Due to excessive serotonin production side effects could include: Nausea, diarrhea, loss of appetite, vomiting, difficult breathing, dilation of pupils, exaggerated reflexes, loss of muscle coordination, blurring of vision and cardiac dysrhythmias.