5-MTHF 5mg 60 Vegetarian Capsules

Folic acid must be converted to its active forms to be used by the body. This is a multi-step biochemical process that occurs in the intestines and liver. In the presence of intestinal or liver dysfunction this conversion may not occur sufficiently enough to meet the body's needs. Furthermore, up to 60-percent of the U.S. population may have a genetic enzyme defect that makes it difficult for them to convert folic acid into active 5-MTHF. For these individuals and many others, 5-MTHF supplementation may be a more effective method of folate repletion.

5-MTHF is an essential cofactor in the metabolism of the amino acid metabolite homocysteine. 5-MTHF also must be present in sufficient quantity for normal production of the neurotransmitters serotonin, melatonin, dopamine, epinephrine, and norepinephrine. These functions make 5-MTHF critical for both cardiovascular function and mood support.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent disease.


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1 capsule

Serving Size:1 capsule

Folate (as L-5-Methyltetrahydrofolate*) 5 mg.

Other Ingredients: Microcrystalline Cellulose, Hypromellose (derived from cellulose) capsule, Leucine, Silicon Dioxide.

*This product uses Gnosis S.p.A.'s L-5-Methyltetrahydrofolate (Extrafolate-S®). Extrafolate-S is a registered trademark of Gnosis S.p.A.

This product does not contain wheat, gluten, corn, yeast, soy, egg, dairy products, or artificial colors, artificial sweeteners, or artificial flavors. This product also does not contain lactose, palmitic acid, magnesium stearate, or stearic acid.

Suggested Use: Take 1 capsule two to three times daily or as recommended by a health-care practitioner.

ALLERGY WARNING: This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients.

PREGNANCY WARNING: If pregnant, consult your health-care practitioner before using this product.

INTERACTIONS: 5-methyl-tetrahydrofolate (5-MTHF) supplementation is not recommended concurrently with methotrexate cancer therapy, as it can interfere with methotrexate's anti-neoplastic activity; however, this folate source has not been shown to interfere with the anti-inflammatory activity of methotrexate. An individual taking methotrexate for psoriasis or rheumatoid arthritis can safely take a supplement containing folate.