Oligomeric proanthocyanidins (OPCs) are comprised of two, three, or more flavonoid molecules attached to each other. OPCs have strong free-radical scavenging (antioxidant) ability, resulting in inhibition of oxidative damage and protection of blood vessels and other tissues. OPCs have been shown to protect vascular endothelial cells from oxidative damage and appear to strengthen the resistance of cell membranes to injury and degradation. They also bind copper and iron, thereby reducing their oxidative effects. A clinical study of 10 healthy volunteers examining the effect of OPC supplementation on markers of oxidative stress showed significantly increased levels of alpha-tocopherol in red blood cell membranes.
The primary ingredient in
O.P.C.-100, Leucoselect Phytosome, markedly elevates blood total antioxidant capacity. In a randomized human trial, young healthy volunteers received Leucoselect Phytosome (containing 300 mg of Leucoselect daily) or a placebo. The blood Total Radical-trapping Antioxidant Parameter (TRAP – a measure of antioxidant activity) was measured at several time-points during day one and day five. Within 30 minutes after administration on day one, blood TRAP levels were significantly elevated compared to placebo. Other studies on Leucoselect Phytosome supplementation have demonstrated a reduction in the oxidation of LDL cholesterol in heavy smokers, reduced oxidative stress in diabetics, and a reduction in oxidative stress after a fatty meal.
Evidence suggests OPCs stabilize collagen cross-linkage within skin and other connective tissues. OPCs have also been shown to decrease capillary permeability (thus decreasing bruising). Clinical studies demonstrate reduced swelling and improved resolution of sports injuries in athletes given OPCs prior to a sporting event.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent disease.
