Glycation in Metabolic Syndrome, Type 2 Diabetes and Aging
Elevated blood sugar (hyperglycemia) is associated with Metabolic Syndrome, Type 2 Diabetes and aging. Chronic elevations of blood sugar leads to a process known as glycation. Glycation refers to the process whereby sugar molecules in the blood and in the cells chemically bond to proteins and DNA in the body. These glycated proteins eventually form what are known as advanced glycation end products, also known as AGE compounds (AGEs). AGEs are a fitting acronym as
these compounds activate the immune system, resulting in the
inflammation and tissue damage associated with accelerated aging and
diabetes.
The Vital and Protective Role of Alpha Lipoic Acid in Blood Sugar Metabolism and Insulin Sensitivity
Numerous studies have explored and affirmed the benefits of Alpha Lipoic Acid (ALA) in insulin function, glucose metabolism, and in it's protective role as an antioxidant. In sugar metabolism, ALA fulfills a critical role as a cofactor for enzymes involved in cellular glucose utilization, and it enhances the role of insulin function in the uptake of glucose into the cells.
As an antioxidant, In ALA mediates a vital and protective role in moderating oxidative stress that is a by product of elevated blood sugar, and elevated lipids (LDL cholesterol, triglycerides),(1) that are typical and concomitant features of Metabolic syndrome (MetS)*, and type 2 diabetes.(2,3)
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